ESR13 – Waning of immunity due to pathogen evolution

ESR13: Waning of immunity due to pathogen evolution

Recruiting beneficiary: University of Szeged, Hungary


Internal supervisors: Dr. Gergely Röst, Dr. Tibor Krisztin


Brief project description: The ESR will develop mathematical models to understand the interplay of population level epidemiological dynamics, within-host immune dynamics, and evolutionary dynamics of the pathogen, starting from an SIRS (susceptible – infected – recovered and immune – susceptible) framework and expanding it to more sophisticated mathematical tools (e.g. nonlinear differential equations with state-dependent delays and structured population models expressed by hyperbolic partial differential equations). These models will be accompanied with agent-based model counterparts, The models will be investigated by analytical and numerical methods and explicit stochastic simulations.